Transcutaneous carbon-dioxide partial pressure trends during six-minute walk test in patients with very severe COPD

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Transcutaneous carbon-dioxide partial pressure trends during six-minute walk test in patients with very severe COPD

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作者：Vasileios Andrianopoulos ; PhD^a ; ^b ; ^{VAndrianopoulos@schoen-kliniken.de" class="auth_mail" title="E-mail the corresponding author} ; Lowie E.G.W Vanfleteren^a ; ^c ; ^{lowievanfleteren@ciro-horn.nl" class="auth_mail" title="E-mail the corresponding author} ; Inga Jarosch^b ; ^{IJarosch@Schoen-Kliniken.de" class="auth_mail" title="E-mail the corresponding author} ; Rainer Gloeckl^b ; ^d ; ^{RGloeckl@Schoen-Kliniken.de" class="auth_mail" title="E-mail the corresponding author} ; Tessa Schneeberger^b ; ^e ; ^{TSchneeberger@Schoen-Kliniken.de" class="auth_mail" title="E-mail the corresponding author} ; Emiel F.M. Wouters^a ; ^c ; ^{ewouters@ciro-horn.nl" class="auth_mail" title="E-mail the corresponding author} ; Martijn A. Spruit^a ; ^f ; ^{martijnspruit@ciro-horn.nl" class="auth_mail" title="E-mail the corresponding author} ; Klaus Kenn^b ; ^e ; ^{KKenn@Schoen-Kliniken.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Bf ; breathing frequency ; BMI ; body mass index ; BGA ; blood gas analysis ; CBG ; capillary blood gas ; COPD ; chronic obstructive pulmonary disease ; CRQ ; chronic respiratory disease questionnaire ; DLCO ; carbon monoxide diffusing capacity ; EID ; exercise-induced oxygen desaturation ; EIH ; exercise-induced hypercapnia ; FEV1 ; forced expiratory volume in 1&thinsp ; second ; HADS ; hospital anxiety and depression scale ; LTOT ; long-term oxygen therapy ; VE ; expired ventilation ; PCCO2 ; capillary carbon-dioxide part
刊名：Respiratory Physiology & Neurobiology
出版年：2016
出版时间：November 2016
年：2016
卷：233
期：Complete
页码：52-59
全文大小：976 K

文摘

•: T_CPCO₂ response to 6MWT is highly heterogeneous in patients with advanced COPD.
•: CO₂ retention (T_CPCO₂ increase of >4 mmHg) is related to worse airflow limitation (FEV₁) and higher pre-walk dyspnea.
•: EIH (T_CPCO₂ levels of >46 mmHg at exertion) during the 6MWT is associated with higher baseline-P_CCO₂ values (≥41 mmHg) and higher pre-walk dyspnea.
•: Overweight/Obese BMI seems to carry a protective effect against EIH in very severe COPD.
•: Monitoring of T_CPCO₂ during 6MWT might help to identify patients who need special attention regarding to EIH.