Novel role of serine racemase in anti-apoptosis and metabolism

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• 作者：Gourango Talukdar^a ; ^b ; Ran Inoue^a ; Tomoyuki Yoshida^a ; Tetsuya Ishimoto^a ; Keisuke Yaku^c ; Takashi Nakagawa^c ; Hisashi Mori^a ; ^{hmori@med.u-toyama.ac.jp}
• 关键词：SR ; serine racemase ; NMDAR ; N-methyl-D-aspartate receptor ; STS ; staurosporine ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; Bcl-2 ; B-cell lymphoma 2 ; BAX ; Bcl-2- associated X protein ; BAD ; Bcl-2-associated death promoter ; VDAC ; voltage-dependent anion channel ; DAO ; D-amino acid oxidase
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3378-3387
• 全文大小：1747 K
• 卷排序：1861

文摘

SR, an enzyme, catalyzes D-serine from L-serine and the produced D-serine acts as a neuronal signaling molecule by NMDA receptor SR produces excessive ATP by utilizing the conventional metabolic pathway in epithelial cell lines High ATP may exacerbate the resistance by phosphorylated apoptotic family proteins SR has role in anti-apoptosis