Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism

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Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism

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作者：J. Patrizia Stohn ; M. Elena Martinez ; Arturo Hernandez ; Ph.D. ; ^{hernaa@mmc.org" class="auth_mail" title="E-mail the corresponding author} (Faculty Scientist II)
关键词：Dio3 ; Hypothyroidism ; Hyperthyroidism ; Anxiety ; Depression ; Hyperactivity
刊名：Psychoneuroendocrinology
出版年：2016
出版时间：December 2016
年：2016
卷：74
期：Complete
页码：46-56
全文大小：2288 K

文摘

•: Decreased anxiety- and depression-like behaviors are associated with increased thyroid hormone action in the brain.
•: Thyroid hormone action in the neonatal and/or adult brain leads to hyperactivity.
•: The type 3 deiodinase deficient mouse resembles some aspects of Attention Deficit and Hyperactive Disorder.

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