Alkaline pH enhances farnesol production by Saccharomyces cerevisiae

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• 作者：Masayoshi  ; Muramatsu¹ ; Chikara  ; Ohto¹ ; Shusei  ; Obata¹ ; Eiji  ; Sakuradani² ; Sakayu  ; Shimizu² ;   ; ^{sim@kais.kyoto-u.ac.jp}
• 关键词：Farnesol ; Farnesyl diphosphate ; Nerolidol ; Prenyl alcohol ; Terpenoid
• 刊名：Journal of Bioscience and Bioengineering
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：108
• 期：1
• 页码：52-55
• 全文大小：353 K

文摘

External environments affect prenyl alcohol production by squalene synthetase-deficient mutant Saccharomyces cerevisiae ATCC 64031. Cultivation of the yeast in medium with an initial pH ranging from 7.0 to 8.0 increased the amount of secreted farnesol (FOH). In contrast, acidic medium with a pH below 4.0 increased the intracellular FOH and its isomer nerolidol. These effects of alkaline pH were also observed on constant pH cultivation in a jar fermenter. On cultivation for 133?h, the FOH production reached 102.8?mg/l.