CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling

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• 作者：Jia-bin Wang^a ; ¹ ; Zu-wei Wang^a ; ¹ ; Yun Li^b ; Chao-qun Huang^c ; Chao-hui Zheng^a ; Ping Li^a ; Jian-wei Xie^a ; Jian-xian Lin^a ; Jun Lu^a ; Qi-yue Chen^a ; Long-long Cao^a ; Mi Lin^a ; Ru-hong Tu^a ; Yao Lin^c ; ^{yaolin@fjnu.edu.cn} ; Chang-ming Huang^a ; ^{hcmlr2002@163.com}
• 关键词：CDK5RAP3 ; GSK-3β ; β-catenin ; Survival ; Gastric cancer
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：188-197
• 全文大小：3856 K
• 卷排序：385

文摘

Down-regulation of CDK5RAP3 in gastric cancer was correlated with poor prognosis. CDK5RAP3 suppressed gastric cancer tumorigenesis via β-catenin inhibition. CDK5RAP3 inhibited β-catenin via GSK-3β phosphorylation suppression. The prognostic value of CDK5RAP3 in gastric cancer depends on β-catenin status.