Alginate microgels loaded with temperature sensitive liposomes for magnetic resonance imageable drug release and microgel visualization

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Alginate microgels loaded with temperature sensitive liposomes for magnetic resonance imageable drug release and microgel visualization

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作者：Merel van Elk^a ; Cyril Lorenzato^b ; Burcin Ozbakir^a ; Chris Oerlemans^b ; ^c ; Gert Storm^a ; Frank Nijsen^c ; Roel Deckers^b ; Tina Vermonden^a ; Wim E. Hennink^a ; ^{W.E.Hennink@uu.nl" class="auth_mail" title="E-mail the corresponding author}
关键词：MRI ; magnetic resonance imaging ; NTSL ; non-temperature sensitive liposomes ; TSL ; temperature sensitive liposomes ; Gd ; gadolinium ; [Gd(HPDO3A)(H2O)] ; Gd complex used as MRI contrast agent (Prohance® ; ) ; Ho ; holmium ; Ba ; barium ; NTSL-Ho-microgels ; holmium crosslinked microgels encapsulating NTSL ; TSL-Ho-microgels ; holmium crosslinked microgels encapsulating TSL ; TACE ; transarterial chemoembolization ; DEB ; drug eluting bead ; DSPC ; 1 ; 2-distearoyl-sn-glycero-3-phosphocholine ; DSPE-PEG2000 ; 1 ; 2-dist
刊名：European Polymer Journal
出版年：2015
出版时间：November 2015
年：2015
卷：72
期：Complete
页码：620-631
全文大小：1754 K

文摘

•: Temperature sensitive liposomes were (TSL) were loaded with a dye and an MRI contrast agent.
•: TSL were loaded into MR-imageable alginate microgels crosslinked with holmium ions.
•: Microgels rapidly release the dye and MRI contrast agent upon hyperthermia (42 °C).
•: Holmium crosslinked microgels were observed in an ex vivo kidney after injection.

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