Plasma disposition, milk excretion and parasitological efficacy of mebendazole in donkeys naturally infected by Cyathostominae

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Plasma disposition, milk excretion and parasitological efficacy of mebendazole in donkeys naturally infected by Cyathostominae

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作者：Cengiz Gokbulut^a ; Dilek Aksit^b ; Mario Santoro^c ; Cristina Roncoroni^d ; Ugo Mariani^c ; Francesco Buono^e ; Domenico Rufrano^f ; Antonio Fagiolo^d ; Vincenzo Veneziano^e ; ^{vincenzo.veneziano@unina.it" class="auth_mail" title="E-mail the corresponding author} ; ^{vinvene@unina.it" class="auth_mail" title="E-mail the corresponding author}
关键词：Donkey ; Mebendazole ; Pharmacokinetics ; Efficacy ; Milk ; Cyathostominae
刊名：Veterinary Parasitology
出版年：2016
出版时间：15 February 2016
年：2016
卷：217
期：Complete
页码：95-100
全文大小：440 K

文摘

•: In donkeys no data are available on Mebendazole (MBZ) pharmacokinetic and effectiveness.
•: Study animals received MBZ paste at 10 mg/kg (labeled horse dosage) and 20 mg/kg.
•: Both MBZ dosageswere efficient (>95% efficacy) until day 28.
•: MBZ has a minimal disposition rate into the milk with zero milk-withdrawal period.
•: Similar dosage regimens of MBZ could be used for horses and donkeys.

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