At baseline, depressed adolescents exhibited reduced connectivity between amygdala and dorsolateral prefrontal cortex.

At baseline, depressed adolescents showed reduced amygdala connectivity with ventromedial prefrontal cortex.

More positive baseline amygdala connectivity with insula was associated with reduced symptom severity three months later.

Indictors of depression absence/presence are distinct from those associated with change in depression symptoms over time.