We used the chronic mild stress model for depression and investigated GABAergic neurons in the orbitofrontal cortex.

We quantified calbindin-, calretinin-, cholecystokinin-, parvalbumin-, NPY- and somatostatin-positive neurons.

We found pronounced stress-induced reduction of calbindin-positive neuron densities in the orbitofrontal cortex.

Stress-resilient rats had increased densities of CCK+ and NPY+ cells in their ventral and lateral orbitofrontal cortex.