First-in-human safety and immunogenicity investigations of three adjuvanted reduced dose inactivated poliovirus vaccines (IPV-Al SSI) compared to full dose IPV Vaccine SSI when given as a booster vaccination to adolescents with a history of IPV vaccination at 3, 5, 12 months and 5 years of age

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• 作者：Line M. Lindgren^b ; Pernille N. Tingskov^a ; Annette H. Justesen^c ; Bettina S. Nedergaard^d ; Klaus J. Olsen^e ; Lars V. Andreasen^a ; Ingrid Kromann^a ; Charlotte Sø ; rensen^a ; Jes Dietrich^a ; Birgit Thierry-Carstensen^a ; ^btc@ssi.dk
• 关键词：Affordable IPV ; IPV dose sparing ; Dose investigation ; Aluminium hydroxide adjuvant
• 刊名：Vaccine
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：35
• 期：4
• 页码：596-604
• 全文大小：1563 K
• 卷排序：35

文摘

Three adjuvanted reduced dose IPV-Al SSI were safe and immunogenic in adolescents. The three IPV-Al SSI were highly immunogenic, but inferior to IPV Vaccine SSI as a booster. Reduced dose IPV-Al SSI is intended for markets in need of affordable IPV.