Regulation of hepatic cardiolipin metabolism by TNF伪: Implication in cancer cachexia

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Regulation of hepatic cardiolipin metabolism by TNF伪: Implication in cancer cachexia

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作者：Laure Peyta^a ; ^{laure.peyta@etu.univ-tours.fr" class="auth_mail" title="E-mail the corresponding author} ; Kathleen Jarnouen^b ; ^c ; ^{kathleen.jarnouen@univ-rennes1.fr" class="auth_mail" title="E-mail the corresponding author} ; Michelle Pinault^a ; ^{michelle.pinault@univ-tours.fr" class="auth_mail" title="E-mail the corresponding author} ; Cedric Coulouarn^b ; ^c ; ^{cedric.coulouarn@univ-rennes1.fr" class="auth_mail" title="E-mail the corresponding author} ; Cyrille Guimaraes^a ; ^{cyrille.guimaraes@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Caroline Goupille^a ; ^d ; ^{caroline.goupille@univ-tours.fr" class="auth_mail" title="E-mail the corresponding author} ; Jean-Paul Pais de Barros^e ; ^{jppais@u-bourgogne.fr" class="auth_mail" title="E-mail the corresponding author} ; Stephan Chevalier^a ; ^{stephan.chevalier@univ-tours.fr" class="auth_mail" title="E-mail the corresponding author} ; Jean-Franç ; ois Dumas^a ; ^{jean-francois.dumas@univ-tours.fr" class="auth_mail" title="E-mail the corresponding author} ; Franç ; ois Maillot^a ; ^d ; ^{maillot@med.univ-tours.fr" class="auth_mail" title="E-mail the corresponding author} ; Grant M. Hatch^f ; ^{ghatch@chrim.ca" class="auth_mail" title="E-mail the corresponding author} ; Pascal Loyer^b ; ^c ; ^{pascal.loyer@univ-rennes1.fr" class="auth_mail" title="E-mail the corresponding author} ; Stephane Servais^a ; ^{stephane.servais@univ-tours.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：ALCAT1 ; acyl&ndash ; CoA ; lysocardiolipin acyltransferase ; CDP&ndash ; DAG ; diphosphate-1 ; 2-diacyl-sn-glycerol ; CDS ; cytidine-5&prime ; -diphosphate-1 ; 2-diacyl-sn-glycerol synthase ; CL ; cardiolipin ; CLS ; cardiolipin synthase ; DMSO ; dimethylsulfoxide ; ETS ; electron transfert system ; FCCP ; carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; Hsc70 ; heat shock cognate 70 ; kDa ; iPLA2纬 ; calcium independent phospholipase A2 gamma ; MLCL AT-1 ; monolysocardi
刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
出版年：2015
出版时间：November 2015
年：2015
卷：1851
期：11
页码：1490-1500
全文大小：865 K

文摘

•: First demonstration of liver cardiolipin metabolism alteration in cancer induced cachexia
•: Direct implication of TNF伪 in mitochondrial energy wasting via cardiolipin modulation
•: Increasing knowledge on cellular mechanism of liver energetic alteration during cancer cachexia