Low doses of ketamine do not alter DA system in zebrafish embryos.
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Anesthetic dose of ketamine and ALCAR reduces DA levels and TH gene expression.
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ALCAR but not ketamine accelerates DA metabolism but does not alter MAO and COMT gene expression.
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Ketamine attenuates MAO gene expression at both sub-anesthetic and anesthetic doses.
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Low doses of ketamine as fast-acting anti-depressants may rely on the ability in suppressing the DA metabolizing enzyme, MAO.
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