Opposing effects of ketamine and acetyl l-carnitine on the serotonergic system of zebrafish

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Opposing effects of ketamine and acetyl l-carnitine on the serotonergic system of zebrafish

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作者：Bonnie L. Robinson ; Melanie Dumas ; Merle G. Paule ; Syed F. Ali ; Jyotshna Kanungo ; ^{jyotshnabala.kanungo@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author}
关键词：Ketamine ; Zebrafish ; Acetyl l-carnitine ; Serotonin ; Metabolism ; HPLC/EC
刊名：Neuroscience Letters
出版年：2015
出版时间：21 October 2015
年：2015
卷：607
期：Complete
页码：17-22
全文大小：1089 K

文摘

•: Low doses of ketamine do not alter 5-HT and 5-HIAA levels in zebrafish embryos.
•: Anesthetic dose of ketamine reduces 5-HT levels and abolishes its metabolism to 5-HIAA.
•: ALCAR reverses the effects of ketamine on the 5-HT level and metabolism.
•: Anesthetic dose of ketamine reduces serotonin-positive cells in the brain.
•: Ketamine and ALCAR are being tested as anti-depressants, these results indicate their possible modes of action on the 5-HT system.

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