Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors

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• 作者：Leslie W. Tari ; Isaac D. Hoffman ; Daniel C. Bensen ; Michael J. Hunter ; Jay Nix ; Kirk J. Nelson ; Duncan E. McRee ; Ronald V. Swanson
• 关键词：Aurora ; AIK ; Kinase ; 2 ; 4 Disubstituted pyrimidine
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 出版时间：1 February 2007
• 年：2007
• 卷：17
• 期：3
• 页码：688-691
• 全文大小：540 K

文摘

The 2.25 Å crystal structure of a complex of Aurora A kinase (AIKA) with cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide 1 is described here. The inhibitor binding mode is novel, with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket, and several induced structural changes in the active-site compared with other published AIK structures. This structure provides context for the available SAR data on this compound class, and could be exploited for the design of analogs with increased affinity and selectivity for AIK.