Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors

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• 作者：Qian Huang ; Ming-Li Sun ; Yuan Chen ; Xin-Yan Li ; Yong-Xiang Wang ; ^{yxwang@sjtu.edu.cn}
• 关键词：ANOVA ; analysis of variance ; CFA ; complete Freund's adjuvant ; ED50 ; half-effective dose ; Emax ; maximum effect ; GNTI ; 5&rsquo ; -guanidinonaltrindole ; HPLC ; high performance liquid chromatography ; LPS ; lipopolysaccharides ; NMDA ; N-methyl-D-aspartate ; STZ ; streptozotocin
• 刊名：Journal of Ethnopharmacology
• 出版年：2017
• 出版时间：20 January 2017
• 年：2017
• 卷：196
• 期：Complete
• 页码：151-159
• 全文大小：1141 K
• 卷排序：196

文摘

Acute bullatine A and dynorphin A additively enhance morphine antinociception. Chronic bullatine A and dynorphin A induce no antinociceptive tolerance. Concurrent bullatine A and dynorphin A inhibit morphine antinociceptive tolerance. Bullatine A antinociception/anti-tolerance are mediated by spinal microglial dynorphin secretion. Our data provide basis for concurrent use of aconitines and morphine in analgesia.