Expression and production of cardiac angiogenic mediators depend on the Trypanosoma cruzi-genetic population in experimental C57BL/6 mice infection

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• 作者：Deena Shrestha^b ; Bijay Bajracharya^b ; Guilherme Paula-Costa^b ; Beatriz C Salles^b ; Ana Luí ; sa J Leite^b ; Ana Paula J Menezes^b ; D&eacute ; bora MS Souza^b ; Laser AM Oliveira^a ; ^b ; Andr&eacute ; Talvani^a ; ^b ; ^c ; ^d ; ^{talvani@nupeb.ufop.br}
• 关键词：Inflammation ; Trypanosoma cruzi ; Angiogenic factors ; chemokines ; VEGF
• 刊名：Microvascular Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：56-63
• 全文大小：959 K
• 卷排序：110

文摘

The Colombian strain of the T. cruzi induces more cardiac TNF and CCL5 expression/production and inflammation in cardiac tissue than the Y strain; The Y strain of the T. cruzi induces more expression/production of VEGF, Ang-1 and Ang-2 than the Colombian strain; The T. cruzi-genetic population defines the pattern of angiogenic/inflammatory mediators in the heart tissue