Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II

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• 作者：Karem Shanab^a ; Eva Schirmer^a ; Eva Wulz^a ; Barbara Weissenbacher^a ; Sigrid Lassnig^a ; Rita Slanz^a ; Germana Fö ; sleitner^a ; Wolfgang Holzer^a ; Helmut Spreitzer^a ; ^{helmut.spreitzer@univie.ac.at"" rel=""nofollow} ; Peter Schmidt^b ; Babette Aicher^b ; Gilbert M&#xfc ; ller^b ; Eckhard G&#xfc ; nther^b
• 关键词：ticancer compounds
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：15 May 2011
• 年：2011
• 卷：21
• 期：10
• 页码：3117-3121
• 全文大小：1022 K

文摘

A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.