Immunization with electroporation enhances the protective effect of a DNA vaccine candidate expressing prME antigen against dengue virus serotype 2 infection

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Immunization with electroporation enhances the protective effect of a DNA vaccine candidate expressing prME antigen against dengue virus serotype 2 infection

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作者：Hui Chen^a ; Xiaoyan Zheng^a ; Ran Wang^a ; Na Gao^a ; Ziyang Sheng^a ; Dongying Fan^a ; Kaihao Feng^a ; Xianzheng Liao^a ; Jing An^a ; ^b ; ^{anjing60@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; ^{anjing@ccmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Ab ; antibody ; ANOVA ; analysis of variance ; CTL ; cytotoxic T lymphocyte ; DV ; dengue virus ; E ; envelope ; ELISA ; enzyme-linked immunosorbent assay ; ELISPOT ; enzyme-linked immunospot assay ; EP ; electroporation ; E ; T ; effector ; target ; FBS ; fetal bovine serum ; GMT ; Geometric mean titer ; HRP ; horseradish peroxidase ; IFN ; interferon ; IHC ; immunohistochemistry ; IL ; interleukin ; IM ; intramuscular ; LD50 ; median lethal dose ; MEM ; minimum essential medium ; MHC ; major histocompatibility complex ; NAb ; neutraliz
刊名：Clinical Immunology
出版年：2016
出版时间：October 2016
年：2016
卷：171
期：Complete
页码：41-49
全文大小：1109 K

文摘

•: pVAX1-D2ME via electroporation induced strong humoral and cellular immunity in mice.
•: pVAX1-D2ME via electroporation immunization elicited effective protection in mice.
•: High IgG and NAb titer were gained in DNA-immunized rabbits via electroporation.
•: Electroporation is more effective to delivery DNA than intramuscular injection.