Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes

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Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes

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作者：Shruthi S. Bhat^a ; ^{shruthi_s_bhat@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author} ; Kim S. Friedmann^a ; ¹ ; ^{kim.friedmann@uks.eu" class="auth_mail" title="E-mail the corresponding author} ; Arne Knö ; rck^a ; ¹ ; ^{arne.knoerck@uni-saarland.de" class="auth_mail" title="E-mail the corresponding author} ; Cora Hoxha^a ; ^{cora.hoxha@uks.eu" class="auth_mail" title="E-mail the corresponding author} ; Petra Leidinger^c ; ^{p.leidinger@mx.uni-saarland.de" class="auth_mail" title="E-mail the corresponding author} ; Christina Backes^d ; ^{c.backes@mx.uni-saarland.de" class="auth_mail" title="E-mail the corresponding author} ; Eckart Meese^c ; ^{hgemee@uniklinik-saarland.de" class="auth_mail" title="E-mail the corresponding author} ; Andreas Keller^d ; ^{andreas.keller@ccb.uni-saarland.de" class="auth_mail" title="E-mail the corresponding author} ; Jens Rettig^b ; ^{jrettig@uks.eu" class="auth_mail" title="E-mail the corresponding author} ; Markus Hoth^a ; ^{markus.hoth@uks.eu" class="auth_mail" title="E-mail the corresponding author} ; Bin Qu^a ; ^{bin.qu@uks.eu" class="auth_mail" title="E-mail the corresponding author} ; Eva C. Schwarz^a ; ^{eva.schwarz@uks.eu" class="auth_mail" title="E-mail the corresponding author}
关键词：CHX ; cycloheximide ; CTL ; Cytotoxic T lymphocytes ; E ; T ; effector to target ratio ; FHL ; familial HLH ; HLH ; hemophagocytic lymphohistiocytosis ; LDH ; lactate dehydrogenase ; LG ; lytic granules ; IS ; immunological synapse ; qRT-PCR ; quantitative real time polymerase chain reaction ; SEA ; staphylococcal enterotoxin A ; Stx8 ; Syntaxin 8 ; SNARE ; soluble N-ethylmaleimide-sensitive factor attachment protein receptor ; TCR ; T cell receptor ; TGN ; trans-Golgi network
刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
出版年：2016
出版时间：July 2016
年：2016
卷：1863
期：7
页码：1653-1664
全文大小：1591 K

文摘

•: Stx8 is among the most abundant Q-SNAREs in human cytotoxic T lymphocytes.
•: Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules.
•: Cytotoxicity in Stx8 down-regulated human cytotoxic T lymphocytes is impaired.