Improved synthesis of antibacterial 3-substituted 6-anilinouracils

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• 作者：Niels Svenstrup ; Alex ; er Kuhl ; Kerstin Ehlert ; Dieter Hä ; bich
• 关键词：Antibacterials ; DNA polymerase IIIC ; Gram-positive bacteria ; Resistance ; Anilinouracils
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2008
• 出版时间：1 June 2008
• 年：2008
• 卷：18
• 期：11
• 页码：3215-3218
• 全文大小：133 K

文摘

3-Substituted 6-anilinouracils, presently the most promising class of inhibitors of the bacterial DNA polymerase in Gram-positive bacteria, have been prepared by a general and straightforward three-step procedure starting from a readily available 1-benzyloxymethyl-protected derivative of 6-chlorouracil.