Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism

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Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism

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作者：Natalie R.S. Goldberg¹ ; ² ; ³ ; Jacqueline Caesar² ; ³ ; Ashley Park² ; Shawn Sedgh² ; Gilana Finogenov² ; Eliezer Masliah⁴ ; Joy Davis² ; ³ ; Mathew Blurton-Jones¹ ; ² ; ³ ; ^{mblurton@uci.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Stem Cell Reports
出版年：2015
出版时间：10 November 2015
年：2015
卷：5
期：5
页码：791-804
全文大小：2892 K

文摘

•: α-Synuclein mice exhibit significant DLB/PDD-associated cognitive and motor deficits
•: Striatal NSC transplantation dramatically improves cognitive and motor function
•: BDNF is necessary for NSC-mediated behavioral improvements
•: NSC-BDNF promotes recovery by regulating dopaminergic and glutamatergic systems

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