Molecular evidence on the protective effect of ellagic acid on phosalone-induced senescence in rat embryonic fibroblast cells

详细信息    查看全文

• 作者：Maryam Baeeri^a ; Saeideh Momtaz^a ; ^b ; Mona Navaei-Nigjeh^a ; ^c ; Kamal Niaz^a ; ^d ; Mahban Rahimifard^a ; Seyedeh Farnaz Ghasemi-Niri^a ; Nima Sanadgol^a ; ^e ; Mahshid Hodjat^a ; Mohammad Sharifzadeh^a ; ^f ; Mohammad Abdollahi^a ; ^d ; ^f ; ^{Mohammad@TUMS.Ac.Ir} ; ^{Mohammad.Abdollahi@UToronto.Ca}
• 关键词：Aging ; Cell cycle ; Ellagic acid ; Inflammatory cytokines ; Oxidative stress ; Phosalone ; Senescence
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：100
• 期：Complete
• 页码：8-23
• 全文大小：3680 K
• 卷排序：100

文摘

PLN enhanced the oxidative stress, inflammatory response, and disrupted cell division. EA dose-dependently deactivated PLN-induced senescence in REFs. EA depressed PLN toxicity through repression of P38 and P53 at the gene and protein levels. EA promoted expression of telomerase in REFs of PLN-induced senescence.