Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP

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Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP

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作者：Bruno Lemieux¹ ; ⁴ ; Nancy Laterreur¹ ; ⁴ ; Anna Perederina² ; Jean-Franç ; ois Noë ; l¹ ; Marie-Line Dubois³ ; Andrey S. Krasilnikov² ; Raymund J. Wellinger¹ ; ^{raymund.wellinger@usherbrooke.ca" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell
出版年：2016
出版时间：19 May 2016
年：2016
卷：165
期：5
页码：1171-1181
全文大小：2668 K

文摘

•: Yeast telomerase contains a P3-like domain, as found in RNase P/MRP
•: This P3-like domain binds the Pop6/7 heterodimer and the Pop1 protein
•: The P3-like domain is essential for telomerase activity on telomeres in vivo
•: rPop1 addition allows telomerase reconstitution with WT RNA in an RRL system

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