Contrasting regional Fos expression in adolescent and young adult rats following acute administration of the antidepressant paroxetine

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Contrasting regional Fos expression in adolescent and young adult rats following acute administration of the antidepressant paroxetine

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作者：Emily A. Karanges^a ; ^{emily.karanges@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Linnet Ramos^a ; ^{lram2611@uni.sydney.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Bruno Dampney^a ; ^{b.dampney@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Anastasia S. Suraev^a ; ^{anastasia.suraev@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kong M. Li^b ; ^{kong.m.li@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Iain S. McGregor^a ; ^{iain.mcgregor@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Glenn E. Hunt^c ; ^{glenn.hunt@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author}
关键词：5-HT ; 5-hydroxytryptamine ; serotonin ; ACTH ; adrenocorticotropic hormone ; AVP ; arginine vasopressin ; BNST ; bed nucleus of the stria terminalis ; CEA ; central amygdala ; CRF ; corticotrophin-releasing factor ; DR ; dorsal raphe ; ELISA ; enzyme-linked immunosorbent assay ; HPA ; hypothalamic-pituitary-adrenal ; HPLC ; high performance liquid chromatography ; i.p. ; intraperitoneal ; KF ; Kö ; lliker Fuse nucleus ; LHb ; lateral habenula ; LPB ; lateral parabrachial nucleus ; MPA ; medial preoptic area ; NACs ; nucleus
刊名：Brain Research Bulletin
出版年：2016
出版时间：March 2016
年：2016
卷：121
期：Complete
页码：246-254
全文大小：2023 K

文摘

•: Paroxetine induced different patterns of Fos expression in adult and adolescent rats.
•: In young adults, more Fos was expressed in the prelimbic cortex and brain stem.
•: In adolescents, more Fos was expressed in serotonergic and dopaminergic regions.
•: After paroxetine, corticosterone levels were higher only in young adult rats.
•: Plasma paroxetine levels were not significantly different between age groups.

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