Immunomodulation of T<sub>H</sub>2 biased immunity with mucosal administration of nanoemulsion adjuvant

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Immunomodulation of T_H2 biased immunity with mucosal administration of nanoemulsion adjuvant

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作者：Anna U. Bielinska^a ; ¹ ; Jessica J. O&rsquo ; Konek^a ; ^b ; ¹ ; ^{jjoz@umich.edu" class="auth_mail" title="E-mail the corresponding author} ; Katarzyna W. Janczak^a ; James R. Baker Jr.^a ; ^b ; ^{jbakerjr@umich.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：alum ; aluminum hydroxide ; cLN ; cervical lymph node ; ELISA ; enzyme-linked immunosorbent assay ; HBs ; hepatitis B surface antigen ; i.m. ; intramuscular ; i.n. ; intranasal ; i.p. ; intraperitoneal ; NE ; nanoemulsion ; ova ; ovalbumin ; Treg ; regulatory T cell
刊名：Vaccine
出版年：2016
出版时间：25 July 2016
年：2016
卷：34
期：34
页码：4017-4024
全文大小：1227 K

文摘

•: Nanoemulsion vaccine adjuvant induces robust antigen specific T_H1-biased immunity.
•: Nanoemulsion vaccine adjuvant suppresses established T_H2 immunity.
•: Efficacy of nanoemulsion vaccine in mice with pre-existing immunity to same antigen.
•: Nanoemulsion vaccines induce IL-10 and regulatory T cells.

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