“Fit-for-purpose” development of analytical and (semi)preparative enantioselective high performance liquid and supercritical fluid chromatography for the access to a novel σ<sub>1</sub> receptor agonist

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“Fit-for-purpose” development of analytical and (semi)preparative enantioselective high performance liquid and supercritical fluid chromatography for the access to a novel σ₁ receptor agonist

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作者：Daniela Rossi^a ; ¹ ; Annamaria Marra^b ; ¹ ; Marta Rui^a ; Stefania Brambilla^b ; Markus Juza^c ; ^{Markus.Juza@cordenpharma.com" class="auth_mail" title="E-mail the corresponding author} ; ^{maju24@sunrise.ch" class="auth_mail" title="E-mail the corresponding author} ; Simona Collina^a ; ^{simona.collina@unipv.it" class="auth_mail" title="E-mail the corresponding author}
关键词：Amylose and cellulose derived CSPs ; Chiral resolution ; Elution order ; Enantioselective HPLC and SFC ; Sigma 1 (σ1) receptor agonist
刊名：Journal of Pharmaceutical and Biomedical Analysis
出版年：2016
出版时间：25 January 2016
年：2016
卷：118
期：Complete
页码：363-369
全文大小：1248 K

文摘

•: Efficient screening for enantioselective analytical and semi-preparative HPLC and SFC results in methods “fit-for-purpose”.
•: Analytical enantiomer separation of (R/S)-2-(4-phenylphenyl)-4-(1-piperidyl)butan-2-ol by HPLC or SFC.
•: Successful scale-up in enantioselective HPLC and SFC resulting in sufficient amounts for determination of chirooptical properties and assignment of absolute configuration in less than two weeks.
•: Selection of elution order for the enantiomers possible.