Effects of Xuebijing injection on microcirculation in septic shock

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• 作者：Liang Wang ; MD ; Zhiyong Liu ; MD ; Zhe Dong ; MM ; Jieyi Pan ; MM ; Xiaochun Ma ; MD ; ^{wlgicu@outlook.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Sepsis ; Microcirculation ; Xuebijing
• 刊名：Journal of Surgical Research
• 出版年：2016
• 出版时间：1 May 2016
• 年：2016
• 卷：202
• 期：1
• 页码：147-154
• 全文大小：620 K

文摘

This study was conducted to investigate whether Xuebijing injection can rectify the dysfunction of microcirculation in septic shock and assessed the microcirculatory parameters directly via orthogonal polarization spectral and software AVA 3.0.

Material and methods

Anesthetized and mechanically ventilated beagle dogs were modeled for septic shock via lipopolysaccharide (LPS) intravenous injection. They were divided randomly into four groups, control group accepted operation only for jejunostomy and cystostomy; LPS group accepted operation and LPS intravenous injection; saline group accepted operation, LPS intravenous injection, and saline resuscitation; XBJ group accepted operation, LPS intravenous injection, saline resuscitation, and Xuebijing injection infusion. The MAP was recorded via right femoral artery catheterization, at the same time, the blood gas analysis was taken via that pathway at the set time points. ScvO₂ was obtained via right jugular vein catheterization at the related time points. Microcirculatory parameters were recorded by orthogonal polarization spectral via the jejunum stoma, and the microcirculation image was analyzed via the software AVA 3.0 later.

Results

Xuebijing injection improved microcirculation of the jejunum villus in canine model of septic shock induced by endotoxin, especially for the proportion of perfused vessels.

Conclusions

Based on the adequate fluid resuscitation, Xuebijing injection plays a helpful role of improving microcirculation in septic shock.