Brain development in adolescents at ultra-high risk for psychosis: Longitudinal changes related to resilience

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• 作者：Sanne de Wit ; MSc^a ; ¹ ; ^{s.dewit@umcutrecht.nl} ; Lara M. Wierenga ; MSc^a ; ¹ ; Bob Oranje ; PhD^a ; Tim B. Ziermans ; PhD^b ; ^c ; Patricia F. Schothorst ; MD PhD^a ; Herman van Engeland ; MD PhD^a ; René ; S. Kahn ; MD PhD^a ; Sarah Durston ; PhD^a
• 关键词：Ultra-high risk ; Psychosis ; Resilience ; MRI ; Functional outcome ; Brain development
• 刊名：NeuroImage: Clinical
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：542-549
• 全文大小：1047 K
• 卷排序：12

文摘

Is brain development different between resilient and non-resilient UHR individuals? We performed a longitudinal MRI study with up to three scans per individual. Resilience was defined by functional outcome at 6-year follow-up. Widespread differences were found, primarily in volume and cortical surface area. Developmental differences may reflect compensatory neural mechanisms.