Super-Enhancers at the Nanog Locus Differentially Regulate Neighboring Pluripotency-Associated Genes

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Super-Enhancers at the Nanog Locus Differentially Regulate Neighboring Pluripotency-Associated Genes

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作者：Steven Blinka¹ ; ² ; Michael H. Reimer Jr.¹ ; ² ; Kirthi Pulakanti² ; Sridhar Rao¹ ; ² ; ³ ; ⁴ ; ^{sridhar.rao@bcw.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：embryonic stem cells ; transcriptional regulation ; super-enhancers ; eRNAs ; long non-coding RNAs
刊名：Cell Reports
出版年：2016
出版时间：27 September 2016
年：2016
卷：17
期：1
页码：19-28
全文大小：1528 K

文摘

•: Genomic editing reveals functional differences in super-enhancer regulation of Nanog
•: −45 enhancer regulates both nearest neighbor genes, Nanog and Dppa3
•: −45 eRNAs specifically regulate Dppa3 by stabilizing chromatin looping

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