Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

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• 作者：Chongyuan Luo¹ ; ² ; ⁴ ; Madeline A. Lancaster³ ; ⁴ ; ⁵ ; Rosa Castanon¹ ; Joseph R. Nery¹ ; Juergen A. Knoblich³ ; ^{juergen.knoblich@imba.oeaw.ac.at} ; Joseph R. Ecker¹ ; ² ; ⁶ ; ^{ecker@salk.edu}
• 关键词：DNA methylation ; epigenome ; organoid ; brain development ; 3D culture
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：17
• 期：12
• 页码：3369-3384
• 全文大小：14108 K
• 卷排序：17

文摘

In vitro and in vivo brain development share epigenomic signatures Extracellular matrix gene expression distinguishes 2D versus 3D differentiation methods Non-CG methylation marks the forthcoming repression of super-enhancers Pervasive demethylation of peri-centromeric regions occurs in human neural cultures