Olfactory ensheathing cells but not fibroblasts reduce the duration of autonomic dysreflexia in spinal cord injured rats

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Olfactory ensheathing cells but not fibroblasts reduce the duration of autonomic dysreflexia in spinal cord injured rats

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作者：Frank Cloutier^a ; ^{fra.cloutier@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Tomas Kalincik^c ; ^d ; Jenny Lauschke^a ; Gervase Tuxworth^b ; Brenton Cavanagh^b ; Adrian Meedeniya^b ; Alan Mackay-Sim^b ; Pascal Carrive^a ; Phil Waite^a
关键词：Olfactory ensheathing cells ; Transplantation ; Spinal cord injury ; Autonomic dysreflexia ; Sympathetic preganglionic neurons ; Mean arterial blood pressure
刊名：Autonomic Neuroscience: Basic and Clinical
出版年：2016
出版时间：December 2016
年：2016
卷：201
期：Complete
页码：17-23
全文大小：765 K

文摘

•: OECs transplanted close to sympathetic preganglionic neurons survived 8 weeks.
•: OECs reduced autonomic dysreflexia 6 and 7 weeks but not at 8 weeks.
•: OECs changed the morphology of sympathetic preganglionic neurons.
•: OECs changed synaptic inputs onto sympathetic preganglionic neurons somata.
•: Comparison with fibroblasts demonstrated that these effects are cell-specific.

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