Neurotrophic factors’ expression was significantly lower in the olfactory bulb from infected mice.
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In vitro infection of OECs resulted in a significant increase of BDNF mRNA expression.
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HMGB1 expression was increased in both olfactory bulb and OEC cultures infected with S. pneumoniae.
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Conditioned medium of OEC/S. pneumoniae induced cleaved caspase-3 expression and NF-κB activation in N13 microglia.
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