Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC

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Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC

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作者：Darren Carwardine^a ; ^{darren.carwardine@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Liang-Fong Wong^b ; ^{l.wong@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; James W. Fawcett^c ; ^{jf108@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Elizabeth M. Muir^d ; ^{emm1@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Nicolas Granger^e ; ^{nicolas.granger@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：Chondroitinase ABC ; Chondroitin sulphate proteoglycan ; Olfactory ensheathing cells ; Olfactory mucosa ; Spinal cord injury ; Gene therapy
刊名：Journal of the Neurological Sciences
出版年：2016
出版时间：15 August 2016
年：2016
卷：367
期：Complete
页码：311-318
全文大小：1117 K

文摘

•: Olfactory ensheathing cells from the mucosa can be genetically modified to secrete chondroitinase ABC.
•: Lentiviral transduction of olfactory ensheathing cells did not change their morphology or cell marker expression (p75^NGF).
•: Chondroitinase ABC production was confirmed using the Morgan-Elson assay and Western blot.

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