Vaccine-mediated immunity to experimental Mycobacterium tuberculosis is not impaired in the absence of Toll-like receptor 9

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Vaccine-mediated immunity to experimental Mycobacterium tuberculosis is not impaired in the absence of Toll-like receptor 9

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作者：Archana Gopalakrishnan^a ; ^b ; Jillian Dietzold^a ; ^b ; Padmini Salgame^a ; ^{salgampa@njms.rutgers.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：TLR ; Toll-like receptor ; TB ; tuberculosis ; BCG ; Bacillus Calmette&ndash ; Gué ; rin ; IL ; Interleukin ; T-bet ; T box transcription factor ; Eomes ; Eomesodermin ; Mtb ; Mycobacterium tuberculosis ; DCs ; dendritic cells ; TCM ; T central memory ; CFU ; colony forming units ; ELISPOT ; enzyme linked immunospot assay ; BMDC ; bone marrow derived dendritic cell ; H ; hematoxylin ; E ; eosin ; TEM ; T effector memory ; CLRs ; C-type lectin receptors ; NOD ; Nucleotide-binding Oligomerization domain ; NLRs ; Nod-like receptor
刊名：Cellular Immunology
出版年：2016
出版时间：April 2016
年：2016
卷：302
期：Complete
页码：11-18
全文大小：1611 K

文摘

•: Vaccination with Mtb auxotroph protects mice from virulent Mtb infection.
•: Vaccine mediated immunity does not depend on TLR2 and TLR9 signaling.
•: IL-12 expression is not impaired in the lungs of TLR9KO mice.

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