Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells

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Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells

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作者：Kenjiro Shirane¹ ; ² ; Kazuki Kurimoto³ ; ⁴ ; Yukihiro Yabuta³ ; ⁴ ; Masashi Yamaji³ ; ⁴ ; ¹⁰ ; Junko Satoh⁵ ; Shinji Ito⁵ ; Akira Watanabe⁶ ; ⁷ ; Katsuhiko Hayashi³ ; ⁸ ; ⁹ ; Mitinori Saitou³ ; ⁴ ; ⁶ ; ⁷ ; ^{saitou@anat2.med.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hiroyuki Sasaki¹ ; ¹¹ ; ^{hsasaki@bioreg.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
刊名：Developmental Cell
出版年：2016
出版时间：10 October 2016
年：2016
卷：39
期：1
页码：87-103
全文大小：4390 K

文摘

•: In vitro primordial germ cell specification from mouse ESCs models in vivo process
•: PGCLC methylome is derived from progressive dilution of epiblast-like cell methylome
•: PRDM14 differentially impacts the hypomethylation in ESCs and PGCLCs
•: Female ESCs, but not PGCLCs, create hypomethylated lamina-associated domains

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