Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis

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• 作者：Elizabeth R. Hughes¹ ; ⁶ ; Maria G. Winter¹ ; ⁶ ; Breck A. Duerkop² ; Luisella Spiga¹ ; Tatiane Furtado de Carvalho³ ; Wenhan Zhu¹ ; Caroline C. Gillis¹ ; Lisa Bü ; ttner¹ ; Madeline P. Smoot¹ ; Cassie L. Behrendt² ; Sara Cherry⁴ ; Renato L. Santos³ ; Lora V. Hooper² ; ⁵ ; Sebastian E. Winter¹ ; ⁷ ; ^{sebastian.winter@utsouthwestern.edu}
• 关键词：gut microbiota ; dysbiosis ; intestinal inflammation ; formate metabolism ; bacterial respiration ; metagenomics
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：8 February 2017
• 年：2017
• 卷：21
• 期：2
• 页码：208-219
• 全文大小：3299 K
• 卷排序：21

文摘

Genes encoding respiratory pathways are overrepresented in the dysbiotic microbiome Utilization of microbiota-derived formate enhances E. coli fitness in the inflamed gut Formate concentrations in the gut are elevated during inflammation-associated dysbiosis During gut inflammation, formate utilization by E. coli requires oxygen respiration