Chlorination by-products of bisphenol A enhanced retinoid X receptor disrupting effects

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Chlorination by-products of bisphenol A enhanced retinoid X receptor disrupting effects

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作者：Na Li^a ; Weiwei Jiang^b ; Mei Ma^a ; ^{mamei@rcees.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Donghong Wang^a ; Zijian Wang^a ; ^{wangzj@rcees.ac.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：TEQ ; toxic equivalent quantity ; BPA ; bisphenol A ; TCP ; 2 ; 4 ; 6-trichlorophenol ; MCBPA ; monochlorobisphenol A ; DCBPA ; dichlorobisphenol A ; T3CBPA ; trichlorobisphenol A ; ER ; estrogen receptor ; RXR ; retinoid X receptor ; TR ; thyroid receptor ; ERRγ ; orphan estrogen-related receptor gamma ; NaClO ; sodium hypochlorite ; GC/MS ; gas chromatography/mass spectrometry ; ICC ; initial chlorine concentration ; EDCs ; endocrine-disrupting chemicals ; 9cRA ; 9-cis-RA () ; DBPs ; disinfection byproducts ; RXRβ-LBD ; RXRβ-liga
刊名：Journal of Hazardous Materials
出版年：2016
出版时间：15 December 2016
年：2016
卷：320
期：Complete
页码：289-295
全文大小：1454 K

文摘

•: Toxicities of BPA chlorination by-products in water to human RXRβ were assessed.
•: RXRβ antagonistic activity increased, while no agonistic activity was detected.
•: Chlorine might act as a toxic potentiator rather than a toxic deactivator.
•: Molecular docking showed BPA by-products may have the same mode of action to RXRβ.

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