Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-β1 signaling, enhancing human breast cancer cell migration and invasion

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Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-β1 signaling, enhancing human breast cancer cell migration and invasion

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作者：Noelia Miret^a ; ^{noeliamiret@hotmail.com.ar" class="auth_mail" title="E-mail the corresponding author} ; Carolina Pontillo^a ; ^{caroponti@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Clara Ventura^b ; ^{clara.ventura.lp@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Alejandro Carozzo^c ; ^{ale.carozzo@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Florencia Chiappini^a ; ^{florenciachiappini@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Diana Kleiman de Pisarev^a ; ^{dianakleiman@yahoo.com.ar" class="auth_mail" title="E-mail the corresponding author} ; Natalia Ferná ; ndez^c ; ^{natycfernandez@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Claudia Cocca^b ; ^{cm_cocca@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Andrea Randi^a ; ^{andybiol@yahoo.com.ar" class="auth_mail" title="E-mail the corresponding author} ; ^{andyrandi15@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：AhR ; aryl hydrocarbon receptor ; ANF ; α-naphthoflavone ; EMT ; epithelial-mesenchymal transition ; ERα ; estrogen receptor α ; ERK1/2 ; extracellular signal related kinase 1 and 2 ; HCB ; hexachlorobenzene ; JNK ; c-jun n-terminal kinase ; TCDD ; 2 ; 3 ; 7 ; 8-tetrachlorodibenzo-p-dioxin ; TGF-β1 ; transforming growth factor-β1 ; TβRI ; type I TGF-β receptor ; TβRII ; type II TGF-β receptor
刊名：Toxicology
出版年：2016
出版时间：29 July 2016
年：2016
卷：366-367
期：Complete
页码：20-31
全文大小：2860 K

文摘

•: HCB enhances TGF-β1 expression and activation levels in breast cancer cells.
•: HCB activates TGF-β1 pathways: Smad3, JNK and p38.
•: The HCB- induced migration and invasion involves TGF-β1 signaling pathways.
•: HCB modulates AhR levels and activation.
•: HCB enhances TGF-β1 mRNA expression in an AhR-dependent manner.