Structural analysis of doxorubicin-polymer conjugates

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Structural analysis of doxorubicin-polymer conjugates

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作者：S. Sanyakamdhorn ; L. Bekale ; D. Agudelo ; H.A. Tajmir-Riahi ; ^{heidar-ali.tajmir-riahi@uqtr.ca" class="auth_mail" title="E-mail the corresponding author}
关键词：Dox ; doxorubicin ; FDox ; N-(trifluoroacetyl) doxorubicin ; PEG ; poly(ethylene glycol) ; mPEG ; methoxypoly (ethylene glycol) ; PAMAM ; poly(amidoamine) ; FTIR ; Fourier transform infrared ; TEM ; transmission electron microscopy
刊名：Colloids and Surfaces B: Biointerfaces
出版年：2015
出版时间：1 November 2015
年：2015
卷：135
期：Complete
页码：175-182
全文大小：3244 K

文摘

•: Dox and FDox bindings to PEG-6000, mPEG-PAMAM-G3 and PAMAM-G4 were characterized.
•: Polymers form more stable conjugate with Dox than FDox.
•: Drug encapsulation alters the morphology of synthetic polymers.
•: Hydrophobicity plays a major role in drug-polymer conjugate formation.
•: PAMAM nanoparticles form more stable drug complexes than mPEG-PAMAM and PEG- 6000.

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