FB
1 was rapidly eliminated from the central compartment (t
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β = 1.1 hr; K
10 = 1.6 hr
−1) and levels less than 20 ng/ml remained within 8 hr after dosing. The short half-life for terminal elimination phase (t
![]()
β) was not related with a high total plasma clearance (CL = 0.071 L/hr). The fate of FB
1 is still unclear, but our results might to support the hypothesis that a FB
1 portion undergoes metabolic activation. Further investigations will be necessary to provide this information.