The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor

详细信息查看全文

作者：Rebecca L. Miller¹ ; ⁶ ; Aaron A. Thompson¹ ; ⁶ ; Claudio Trapella² ; Remo Guerrini² ; Davide Malfacini³ ; Nilkanth Patel⁵ ; Gye Won Han⁴ ; Vadim Cherezov⁴ ; Girolamo Caló ; ³ ; Vsevolod Katritch⁵ ; Raymond C. Stevens¹ ; ⁴ ; ⁵ ; ^{stevens@usc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Nociceptin/orphanin FQ peptide receptor ; NOP ; ORL-1 ; N/OFQ ; opioid receptor ; G protein-coupled receptor ; GPCR ; membrane protein ; lipidic cubic phase ; BRET ; receptor-ligand conformational pair
刊名：Structure
出版年：2015
出版时间：1 December 2015
年：2015
卷：23
期：12
页码：2291-2299
全文大小：2055 K

文摘

•: A correlation is demonstrated between receptor stability and BRET functional data
•: Two antagonist-bound crystal structures of the N/OFQ peptide receptor are reported
•: Docking indicates degenerate binding modes contribute to poor receptor stabilization
•: A mechanism for antagonist-induced receptor stabilization is proposed

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.