Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging

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• 作者：Robert M. Brosh Jr. ; ^{broshr@mail.nih.gov} ; Marina Bellani ; Yie Liu ; Michael M. Seidman ; ^{seidmanm@mail.nih.gov}
• 关键词：Fanconi Anemia ; Aging ; DNA repair ; Bone marrow failure ; Hematopoietic stem cells ; Inflammatory response ; Oxidative stress ; Epigenetic ; Telomere
• 刊名：Ageing Research Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：Complete
• 页码：67-75
• 全文大小：2503 K
• 卷排序：33

文摘

Fanconi Anemia displays features commonly associated with normal aging. Accelerated decline of hematopoietic stem cells is characteristic of Fanconi Anemia. Oxidative stress and inflammation underlie defects observed in Fanconi Anemia. Understanding pathology of Fanconi Anemia may provide insights for healthy aging.