Synthesis, characterization and biological evaluation of ruthenium(II) complexes [Ru(dtzp)(dppz)Cl]+ and [Ru(dtzp)(dppz)CH3CN]2+ for photodynamic therapy

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Synthesis, characterization and biological evaluation of ruthenium(II) complexes [Ru(dtzp)(dppz)Cl]⁺ and [Ru(dtzp)(dppz)CH₃CN]²⁺ for photodynamic therapy

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作者：Hui-juan Yu^a ; Jiang-ping Liu^b ; Zhi-feng Hao^a ; Jun He^a ; Ming Sun^a ; Sheng Hu^a ; Lin Yu^a ; ^{gych@gdut.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Hui Chao^b ; ^{ceschh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Photodynamic therapy ; Photocytotoxicity ; Anticancer drugs ; Spectra titration ; Ruthenium complex
刊名：Dyes and Pigments
出版年：2017
出版时间：January 2017
年：2017
卷：136
期：Complete
页码：416-426
全文大小：1884 K

文摘

•: Two new ruthenium complexes have been synthesized and characterized.
•: Complex 1 shows great photocytotoxicity towards Hela cells (IC₅₀ = 1.9 μM).
•: Complex 1 inhibits Hela cell proliferation by induction of G₂M phase cycle arrest and cells apoptosis.