The effects of levonorgestrel on FSH-stimulated primary rat granulosa cell cultures through gene expression profiling are associated to hormone and folliculogenesis processes

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• 作者：Saú ; l Lira-Albarr&aacute ; n<sup>asup><sup> ; sup><sup>saul.liraa@incmnsz.mxsup> ; Marco F. Larrea-Schiavon<sup>bsup><sup> ; sup><sup>marcof80@gmail.comsup> ; Leticia Gonz&aacute ; lez<sup>asup><sup> ; sup><sup>leti1903@yahoo.com.mxsup> ; Marta Durand<sup>asup><sup> ; sup><sup>mdurand65@gmail.comsup> ; Claudia Rangel<sup>bsup><sup> ; sup><sup>crangel@inmegen.gob.mxsup> ; Fernando Larrea<sup>asup><sup> ; sup><sup>fernando.larreag@incmnsz.mxsup>
• 关键词：Contraception ; Gene transcription ; Granulosa cells ; Levonorgestrel
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：337-345
• 全文大小：1367 K
• 卷排序：439

文摘

Levonorgestrel inhibited hFSH-induced estradiol biosynthesis in rat granulosa cells. The mechanism of aromatase inhibition is post-cAMP at the level of gene transcription. Levonorgestrel alters FSH-responsive genes involved in folliculogenesis. Progesterone-mediated oocyte maturation genes are modified by levonorgestrel. The ovary is a target for levonorgestrel contraceptive effects.