A two-step synthetic strategy to obtain a water-soluble derivative of curcumin with improved antioxidant capacity and in vitro cytotoxicity in C6 glioma cells

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• 作者：José ; M. Landeros<sup>asup> ; Fernando Belmont-Bernal<sup>asup> ; Alma Teresa Pé ; rez-Gonz&aacute ; lez<sup>bsup> ; Mario Israel Pé ; rez-Padró ; n<sup>bsup> ; Patricia Guevara-Salazar<sup>csup> ; Irma Gabriela Gonz&aacute ; lez-Herrera<sup>bsup> ; Patricia Guadarrama<sup>asup><sup> ; sup><sup>patriciagua@iim.unam.mxsup>
• 关键词：Curcumin ; Polyester dendrons ; Solubility enhancement ; Antioxidant capacity
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：351-362
• 全文大小：2486 K
• 卷排序：71

文摘

Novel water-soluble derivative of curcumin with therapeutic potential was synthesized. The two-step synthesis from accessible raw materials was reproducible at all time. The dendronization of curcumin confers an optimal hydrophilic/hydrophobic balance. The novel compound exhibited an increased antioxidant activity compared with curcumin. The new compound is cytotoxic in C6 cells by a different mechanism to curcumin.