Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response

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Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response

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作者：Lin-Lin Ma^a ; Hui-Qiang Wang^a ; Ping Wu^b ; Jin Hu^a ; Jin-Qiu Yin^a ; Shuo Wu^a ; Miao Ge^a ; Wen-Fang Sun^a ; Jiang-Yu Zhao^c ; Haji Akber Aisa^c ; Yu-Huan Li^a ; ^{yuhuanlibj@126.com" class="auth_mail" title="E-mail the corresponding author} ; Jian-Dong Jiang^a ; ^b ; ^{Jiang.jdong@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：IAV ; influenza A virus ; HO-1 ; heme oxygenase-1 ; Nrf2 ; erythroid 2-related factor 2 ; ISGs ; IFN-stimulated genes ; RdRp ; RNA-dependent RNA polymerase ; TLRs ; toll-like receptors ; RLR ; RIG-I-like receptors ; MKP5 ; MAPK phosphatase 5 ; IRF3 ; interferon regulatory factor 3 ; HIV ; human immunodeficiency virus ; HCV ; hepatitis C virus ; HBV ; hepatitis B virus ; EBOV ; Ebola virus ; OC ; oseltamivir carboxylate ; AH ; amantadine hydrochloride ; RBV ; ribavirin ; OP ; oseltamivir phosphate ; MRC-5 ; human fetal lung fibrob
刊名：Free Radical Biology and Medicine
出版年：2016
出版时间：July 2016
年：2016
卷：96
期：Complete
页码：347-361
全文大小：5885 K

文摘

•: Rupestonic acid derivative YZH-106 inhibits the replication of influenza virus through up-regulating HO-1.
•: HO-1 induces the expression of type I IFNs possibly independent of its enzymatic activities.
•: HO-1 might be a promising host target for antiviral therapeutics against influenza and other viral infectious diseases.

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