Current perspectives on the role of orbital fibroblasts in the pathogenesis of Graves' ophthalmopathy

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Current perspectives on the role of orbital fibroblasts in the pathogenesis of Graves' ophthalmopathy

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作者：Willem A. Dik ; ^{w.dik@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} ; Sita Virakul ; Leendert van Steensel
关键词：Graves' ophthalmopathy ; Orbital fibroblast ; Adipocyte ; Fibrocyte ; Inflammation ; Fibrosis ; Cytokine ; Growth factor ; Hyaluronan
刊名：Experimental Eye Research
出版年：2016
出版时间：January 2016
年：2016
卷：142
期：Complete
页码：83-91
全文大小：946 K

文摘

•: Orbital fibroblasts are key cells in the pathogenesis of Graves' ophthalmopathy.
•: Orbital fibroblasts are targets for autoantibodies in Graves' ophthalmopathy.
•: Orbital fibroblasts display a hyper-responsive phenotype.
•: Orbital fibroblasts consist of different subpopulations.
•: Fibrocytes contribute to Graves' ophthalmopathy.

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