Histamine induces NF-κB controlled cytokine secretion by orbital fibroblasts via histamine receptor type-1

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Histamine induces NF-κB controlled cytokine secretion by orbital fibroblasts via histamine receptor type-1

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作者：Sita Virakul^a ; ^b ; Tanachaporn Phetsuksiri^a ; Conny van Holten-Neelen^a ; Benjamin Schrijver^a ; Leendert van Steensel^a ; Virgil A.S.H. Dalm^a ; ^b ; Dion Paridaens^c ; Willem A. van den Bosch^c ; P. Martin van Hagen^a ; ^b ; ^c ; Willem A. Dik^a ; ^{w.dik@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author}
关键词：Histamine ; Histamine receptor type-1 ; Mast cell ; Orbital fibroblast ; Graves&rsquo ; ophthalmopathy ; NF-κB controlled cytokine ; Loratadine ; NF-κB inhibitor
刊名：Experimental Eye Research
出版年：2016
出版时间：June 2016
年：2016
卷：147
期：Complete
页码：85-93
全文大小：897 K

文摘

•: Mast cell numbers are increased in Graves’ ophthalmopathy orbital tissue.
•: Histamine stimulates the production of IL-6, IL-8 and CCL2 by orbital fibroblasts.
•: Histamine does not stimulate hyaluronan production by orbital fibroblasts.
•: Orbital fibroblasts express HRH1, loratadine and SC-514 inhibit histamine-induced cytokine production by orbital fibroblasts.
•: Mast cells, their mediators and downstream receptors might represent therapeutic targets in Graves’ ophthalmopathy.

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