Basic FGF and PDGF-BB synergistically stimulate hyaluronan and IL-6 production by orbital fibroblasts

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Basic FGF and PDGF-BB synergistically stimulate hyaluronan and IL-6 production by orbital fibroblasts

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作者：Sita Virakul^a ; ^b ; ¹ ; Judith W. Heutz^c ; ¹ ; Virgil A.S.H. Dalm^a ; ^b ; Robin P. Peeters^c ; Dion Paridaens^d ; Willem A. van den Bosch^d ; Nattiya Hirankarn^e ; P. Martin van Hagen^a ; ^b ; ^d ; Willem A. Dik^a ; ^{w.dik@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author}
关键词：Graves&rsquo ; ophthalmopathy ; Platelet-derived growth factor-BB ; Fibroblast growth factor ; Vascular endothelial growth factor ; Orbital fibroblast ; Hyaluronan
刊名：Molecular and Cellular Endocrinology
出版年：2016
出版时间：15 September 2016
年：2016
卷：433
期：Complete
页码：94-104
全文大小：528 K

文摘

•: bFGF stimulates proliferation and hyaluronan production, but not IL-6 production, by orbital fibroblasts.
•: bFGF and PDGF-BB synergistically enhance hyaluronan and IL-6 production by orbital fibroblasts.
•: bFGF may contribute to orbital inflammation and tissue remodeling in GO, especially by synergistic interaction with PDGF-BB.
•: VEGF hardly affects orbital fibroblast activity.
•: The receptor tyrosine kinase inhibitor nintedanib efficiently blocks bFGF + PDGF-BB-induced IL-6 and hyaluronan production.

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