An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu)

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An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu)

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作者：Mia Song^a ; Qianjing He^a ; Benjamin-Andreas Berk^b ; John H. Hartwig^a ; Thomas P. Stossel^a ; Fumihiko Nakamura^a ; ^{fnakamura@partners.org" class="auth_mail" title="E-mail the corresponding author}
关键词：Filamin ; RhoGDI2 ; Phosphorylation ; Src ; Mechanotransduction ; Phosphomimetic mutant
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：15 January 2016
年：2016
卷：469
期：3
页码：659-664
全文大小：881 K

文摘

bel">•: RhoGDI2 is identified as a potential filamin A (FLNA)-binding partner.
bel">•: Phosphomimetic mutant, RhoGDI2(Tyr153Glu) interacts with FLNA.
bel">•: RhoGDI2 phosphorylated (Tyr153) by src kinase does not interact with FLNA.
bel">•: Mutation of Tyr-153 to Glu of RhoGDI2 does not mimic phosphorylation.
bel">•: RhoGDI2(Tyr153Glu) provokes an adventitious interaction with FLNA.

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